De Gallardo Spyder van Lamborghini was een 2-deurs cabriolet en was op de automarkt sinds 2006. De bouw is in 2014 beëindigd.
| Type | Motor | Transmissie | Inhoud |
| Gallardo Spyder | benzine | handm. 6 | 5.0 liter |
| LP560-4 | benzine | handm. 6 | 5.2 liter |
| LP570-4 Performance | benzine | handm. 6 | 5.2 liter |
| Gallardo Spyder | benzine | tiptronic 6 | 5.0 liter |
| LP550-2 | benzine | tiptronic 6 | 5.2 liter |
| LP560-4 | benzine | tiptronic 6 | 5.2 liter |
| LP570-4 Performance | benzine | tiptronic 6 | 5.2 liter |